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Integrating high-resolution tissue-clearing imaging, single-cell transcriptomics, and proteomics, the schematic depicts vascular-lymphatic dysregulation in BRONJ, with EC subtype shifts, stromal-immune remodeling, and zoledronate-induced COL2A1-CD44/SDC4 axis.

Journal: bioRxiv

Article Title: Vascular and Lymphatic Dysregulation via Non-EndoMT Col2a1 Signaling in Bisphosphonate-Related Osteonecrosis of the Jaw

doi: 10.1101/2025.09.27.678999

Figure Lengend Snippet: Integrating high-resolution tissue-clearing imaging, single-cell transcriptomics, and proteomics, the schematic depicts vascular-lymphatic dysregulation in BRONJ, with EC subtype shifts, stromal-immune remodeling, and zoledronate-induced COL2A1-CD44/SDC4 axis.

Article Snippet: To establish a murine model of bisphosphonate-related osteonecrosis of the jaw (BRONJ), zoledronate (200 μg/kg; MCE, HY-13777) or an equal volume of saline (vehicle control) was administered intraperitoneally three times per week from day 1 to day 56.

Techniques: Imaging, Single-cell Transcriptomics